Research and Publications

Neuropsychologists Actively Involved in Research

 

Neuropsychology

Cognitive Remediation
We are currently examining the effectiveness of our cognitive remediation program by pre- and post-testing patients who have received cognitive remediation and evaluating the engagement of parents as a moderating variable.

Neurodevelopmental Issues Associated with Congenital Heart Disease
The team is analyzing one- and two-year old neurodevelopmental follow-up in children with congenital heart disease (CHD) to look at inflammatory markers related to brain injury pre- and post-open heart surgery.

We are also collecting comprehensive neuropsychological test results using a standardized core battery from nearly all cardiac transplant and CHD children/adolescents to explore school-age and adolescent outcomes. We are also looking at the cognitive effects of CHD in an fMRI and DTI study.

Concussion
We are also comparing concussed athletes with normal controls to assess advanced neuroimaging techniques as it pertains to return-to-play decisions.

In an additional concussion study, We are using a computerized test of neurocognitive functioning (CNS Vital Signs) to look at pediatric concussion at various times following concussion.

Rehabilitation
We are currently monitoring and tracking recovery as well as identifying predictors of outcomes for patients who have sustained a moderate to severe traumatic brain injury (TBI) during inpatient rehabilitation. 

We are also collecting data to examine the neurocognitive profile of children with anti-NMDA receptor encephalitis. Our goal is to characterize the nature of cognitive deficits following initial diagnosis and treatment, identify predicators of outcome and investigate the trajectory of recovery during the initial years following diagnosis.

Neurodevelopmental Issues Associated with Premature Birth
We are assessing infants in the Neonatal Intensive Care Unit (NICU), who have been diagnosed with a neurological condition (cerebral palsy or stroke for example) and will be following these children during early childhood to assess developmental trajectories and aid in the identification of at-risk infants.

Publications, Presentations and Research

  • Publications

      Howarth, R.A., Reisner, A., Chern, J., Hayes, L., Burns, T.G., & Berenstein, A. (2015). Neurocognitive improvements following endovascular repair for Vein of Galen arteriovenous malformation in childhood: A case report. Journal of Neurosurgery: Pediatrics, 15, 197-202.

      Burns, T.G. & Loring, D.W (2015). Psychological and social impact of epilepsy: pediatric and adolescent review. Journal of Pediatric Epilepsy, 4(3), pp. 1-7.

      Reisner, A., Popoli, D.M., Burns, T.G., Marshall, D.L., Jain, S., Hall, L., Vova, J.A., Kroll, S., Wesselman, B.C., Palasis, S., Hayes, L., Clark, G., Speake, K.M., Holbrook, B.H., Wiskind, R.H., Licata, R.M., Ono, K.E., Hogan, E., Chern, J., DeGrauw, T. (2015). The Central Role of Community Practicing Pediatricians in Contemporary Concussion Care: A Case Study of CHOA’s Concussion Program. Clinical Pediatrics, pp. 1-7

      Bodin, D., Roper, B., O’Toole, K., & Haines, M.E. (2015). Postdoctoral training in clinical neuropsychology: A review of the history, trends, and current issues. Training and Education in Professional Psychology.

      McManus, S. & O’Toole, K. (2014). Book Review: Language Disorders in Children and Adolescents, by Joseph H. Beitchman & Elizabeth B. Brownlie. Child Neuropsychology. Published online: 23 May, 1-3.

      Howarth, R.A., Adamson, A.M., Ashford, J.M., Merchant, T.E., Ogg, R.J., Schulenberg, S.E., Ogg, S., Li, J., Wu, S., Xiong, X, & Conklin, H.M. (2014). Investigating the relationship between COMT polymorphisms and working memory performance among childhood brain tumor survivors. Pediatric Blood & Cancer, 61, 40-45.

      Jackson, S., Patay, Z., Howarth, R.A., Panandiker, A.S., Onar-Thomas, A., Gajjar, A., & Broniscer, A. (2013). Clinico-radiologic characteristics and neurocognitive assessment of long-term survivors of diffuse intrinsic pontine glioma. Journal of Neuro-Oncology, 114, 339-344.

      Howarth, R.A., Ashford, J.M., Merchant, T.E., Ogg, R.J., Santana, V., Wu, S., Xiong, X., & Conklin, H.M. (2013). The utility of parent report in the assessment of working memory among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 19, 380-389.

      Alriksson-Schmidt, A.I., Thibadeau, J.K., Swanson, M.E., Marcus, D., Carris, K.L., Siffel, C., Ward, E., (2013). The Natural History of Spina Bifida in Children Pilot Project: A Research Protocol. JMIR Research Protocols (2013)

      Sun, B., Berl, M.M., Burns, T.G., Gaillard, W.D., Hayes, L., Adjouadi, M., & Jones, R.A (2013). Age Association of Language Task Induced Deactivation Induced in a Pediatric Population. Neuroimage, 65, 232-33.

      Burns, T.G., King, T.Z., & Spencer, K.S. (2012). Mullen Scales of Early Learning: The Utility in Assessing Children with Autism Spectrum Disorders, Cerebral Palsy, and Epilepsy. Journal of Applied Neuropsychology: Child, 1, pp. 1-10.

      Sun, B., Brown, R.C., Hayes, L., Burns, T.G., Huamani, J., Bearden, D.J., & Jones, R.A. (2012). White matter damage in asymptomatic patients with sickle cell anemia: Screening with diffusion tensor imaging. American Journal of Neuroradiology, 33, pp. 1-7.

      Burns, T.G. (2012). Book Review: Sherman, E.M.S., & Brooks, B.L. (Eds). (2012). Pediatric forensic Neuropsychology. New York, NY: Oxford University Press. Applied Neuropsychology: Child, (In press)

      Christopher, G. & O’Toole, K. (2012). Book Review: Barkley, Russell. Executive Functions. New York: Guilford Press. “The chasm cries out for a bridge.” Child Neuropsychology, iFirst, 1-4.

      Micklewright, J.L., King, T.Z., O’Toole, K., Henrich, C., & Floyd, F.J. (2012). Authoritarian Parenting Partially Mediates the Relationship between Parental Stress and Child Adaptive Outcomes 12-36 Months Following Traumatic Brain Injury. Journal of the International Neuropsychological Society, 18, 1-8.

      Conklin, H.C., Ashford, J.A., Howarth, R.A., Merchant, T.E., Ogg, R.J., Santana, V., et al. (2012). Working memory performance among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 18, 996-1005.

  • Presentations

      National Academy of Neuropsychology, November 2015

      Christian, B., Kiefel, J., DiQuattro, M. (2015). The Necessity of using Multiple Measures of Performance Validity in Neuropsychological Testing: A Case Study of Adolescent Concussion. Poster to be presented at the Annual National Academy of Neuropsychology, Austin, Texas.

      DiQuattro, M., Whipple, B., Kiefel, J. (2015). The Evaluation of Processing Speed in Pediatric Concussion: Computerized versus Traditional Neuropsychological Measures. Poster to be presented at the Annual National Academy of Neuropsychology, Austin, Texas.

       

      American Academy of Clinical Neuropsychology, June 2015

      Upshaw, N., Jay, M., Rosenberg, J., & Howarth, R.A. (June 2015). Cognitive and Linguistic Scale (CALS): Utility to Track TBI Recovery in Children and Adolescents during Inpatient Rehabilitation. Poster presented at the 13th Annual Conference of the American Academy of Clinical Neuropsychology, San Francisco, California.

      Jay, M., Upshaw, N., Rosenberg, J., & Howarth, R.A. (June 2015). Tracking the Early Recovery of Anti-NMDA  Receptor Encephalitis in the Pediatric Population Using the Cognitive and Linguistic Scale (CALS). Poster presented at the 13th Annual Conference of the American Academy of Clinical Neuropsychology, San Francisco, California.

      Wilkinson-Smith, A., Howarth, R.A., Greenberg, B., Ayers, A., Plumb, P., & Hughes, S. (June 2015). Behavioral and adaptive functioning in young children with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. Poster presented at the 13th Annual Conference of the American Academy of Clinical Neuropsychology, San Francisco, California.

      O’Toole, K. and Heffelfinger, A. (2015). Postdoctoral Residency Training in Neuropsychology: Structure, Procedures, and Outcomes. Oral presentation at the annual meeting of the American Academy of Clinical Neuropsychology, San Francisco, California.

       

      Society of Pediatric Psychology, April 2015

      Schoffner, K. (2015). Behavioral Treatment for Agitated and Aggressive Behavior Secondary to Anti-NMDA Receptor Encephalitis in the Pediatric Day Rehabilitation Setting. Poster presentation at the Society of Pediatric Psychology  Annual Conference, San Diego, California.

      Gutiérrez-Colina, A., Eaton, C., McManus, S., O’Toole, K. & Blount, R. (2015). Evaluation of the Efficacy of a Cognitive Remediation Intervention Program. Poster presented at annual meeting of The Society of Pediatric Psychology, San Diego, California.

       

      Society of Pediatric Psychology, March 2014

      Gutiérrez-Colina, A., Eaton, C., McManus, S., O’Toole, K. & Blount, R. (2014). Evaluation of the Feasibility and Preliminary Efficacy of a Cognitive Remediation Intervention Program. Annual Meeting Society of Pediatric Psychology, Philadelphia.

       

      International Neuropsychological Society, February 2014

      Christopher, G.B. & Howarth, R.A. (February 2014). Neurocognitive Outcomes in Adolescents  during Acute Recovery from Anti-NMDA Receptor Encephalitis. Poster presented at the 42nd Annual Conference of the International Neuropsychological Society, Seattle, Washington.

       

      American Academy of Clinical Neuropsychology, June 2014

      Bodin, D., McManus, S., O’Toole, K., Rey-Casserly, C., & Slomine , B.(2014) Workshop in: Supervision in Pediatric Neuropsychology: Ethical, Practical, and Structural Issues, 12th Annual Conference of the American Academy of Clinical Neuropsychology, New York, New York.

       

      International Neuropsychological Society, February 2013

      Hudepohl, M.B., Ilardi, D., Christopher, G., & Howarth, R.A. (February 2013). Caring for Pediatric Patients during Inpatient Rehabilitation after Acquired Brain Injury: What Predicts Caregiver Confidence? Poster presented at the 41st Annual Conference of the International Neuropsychological Society, Waikoloa, Hawaii.

  • Ongoing Funded Research

      Loring, D.W. (2013). Cognitive AED Outcomes in Pediatric Localization Related Epilepsy (COPE). Funded by the Patient-Centered Outcomes Research Institute. (Burns, T.G.)

      Burns, T.G., King, T.Z., Jones, R.A., Sun, B., Hayes, L. (2012). Sports Related Concussion: A Comparison of Advanced Neuroimaging and Neurocognitive Factors Predicting Return to Play Decisions. Direct Costs - $50,000 received from Children’s Center for Neurosciences Research. 

      Ware, R.E., Davis, B.R., Adams, R.J., Brown, C., Jones, R.A., Bearden, D., & Burns, T.G., O’Toole, K. (2012). TCD With Transfusions Changing to Hydoxyurea (TWiTCH): A Phase III randomized clinical trial to compare standard therapy (erythrocyte transfusions) with alternative therapy (hydoxyurea) for the maintenance of lowered TCD velocities in pediatric subjects with sickle cell anemia and abnormal pre-treatment TCD velocities. Sponsored by the National Heart, Lung, and Blood Institute. 

      Drossner, D., Mahle, W., Burns, T.G., King, T., Beery, S. (2011). Adolescent and adult cognitive effects from congenital cardiac disease. Funded by the Emory-Children’s Center for Cardiovascular biology and Center for Clinical Outcomes research and Public Health. Direct Costs - $50,000. 

      Drossner, D., Mahle, W., Burns, T.G., King, T., Beery, S. (2011). Adolescent and adult cognitive effects from congenital cardiac disease. Funded by the Emory-Children’s Center for Cardiovascular biology and Center for Clinical Outcomes research and Public Health. Direct Costs - $50,000. 

      Robson, M., Ford, J., Yaleman, N., Cheung, W, Phillips, P., Sahmoud, T (2010). A randomized, double blind, placebo-controlled study of RAD001 in the treatment of patients with subependymal giant cell astrocytomas associated with tuberous sclerosis complex. Noavartis: Protocol CRAD001M2301. 

      Mahle, W., Hamrick, S. et al. (2010). Role of inflammatory response in brain injury following neonatal cardiac surgery. Thrasher Research Fund. Emory University, Department of Pediatrics and Children’s Healthcare of Atlanta – Sibley Heart Center. (Ilardi, D. – Co-Investigator). 

      Gaillard, W.D., Sun, B., Berl, M.M., Burns, T.G., Gaillard, W.D., Hayes, L., Adjouadi, M., & Jones, R.A (2010-2012). Multi-Site Pediatric Network for fMRI Mapping in Childhood Epilepsy. Grant funding from the American Epilepsy Society, NINDS R01 NS44280, Partnership for Pediatric Research Epilepsy Foundation; Children’s Research Institute Avery Award, Intellectual and Developmental Disabilities Research Center at Children’s National Medical Center (NIH IDDRC P30HD40677) and the General Clinic Research Center (NIH GCRC M01-RR13297). The authors are also thankful for the support provided by the National Science Foundation under grants HRD-0833093, CNS-0959985, and CNS-1042341. 

      Brown, C., Jones, R., & Burns, T.G. (2012). Neuroimaging Study of Iron-Associated Neurotoxicity in children diagnosed with Sickle Cell Disease (N-SINC). Funded by Friends of Children’s. Direct Costs: $50,000.

  • Research

      Luton, L., Reed-Knight, B., Loiselle, K., O’Toole, K., & Blount, R. (2011). A Pilot Study Evaluating an Abbreviated Version of the Cognitive Remediation Program for Youth with Neurocognitive Deficits. Brain Injury 25(4), 409-415.

      Moreno-De-Luca, A. Helmers; S.L., Mao, H. Burns, T.G., Melton, A. M. A., Schmidt, K.R.,Fernhoff, P.M.; Ledbetter, D.H.  (in press).  Adaptor protein complex-4 (AP-4)deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability.  Journal of Medical Genetics.

      O’Toole, K. (2011).  Biography of Marcel Kinsbourne, M.D. In J. Kreutzer, J. DeLuca & B. Caplan (Eds.)Encyclopedia of Clinical Neuropsychology. Berlin: Springer Publishing Co.

      Whigham, K.B., Burns, T.G., & Lageman, S.K. (2011). The National Institute of Neurological Disorders and Stroke. In J. Kreutzer, J. DeLuca, & B. Caplan (Eds.), Encyclopedia of Clinical Neuropsychology. Springer Publications

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