Pediatric Neurosciences Research

Neurosurgery

At Children's we know that there is a symbiotic relationship between research and advancing clinical care. We are committed to collaborating with other institutions to initiatve and conduct research to discover preventitive, diagnostic and wellness strategies for children with serious medical illnesses or challenges.

     
 
CenterforNeurosciencesResearch

    Our team is dedicated to finding cures for pediatric neurological diseases. In 2012, we launched the Children’s Center for Neurosciences Research in collaboration with Emory University, Georgia Institute of Technology and the Morehouse School of Medicine. Learn more.

 
     
Brain
  • Brain Tumor

    Migrating Tumor Cells with Nanotechnology

    Barun Brahma, M.D.Tobey MacDonald, M.D. and researchers from Georgia Tech and Emory University published ground-breaking brain tumor research in Nature. This new treatment approach uses nanotechnology to direct tumor cells outside of the brain where they can be captured and killed. Learn more.
    • In 2010, the EUREKA grant was awarded to the Georgia Institue of Technology to enable the design of a treatment for brain tumors that would direct moving tumor cells through a scaffold to a sink, located on the brain’s surface beneath the dura, which would contain a drug to kill the cells. Barun Brahma, M.D.Tobey MacDonald, M.D., and Ravi Bellamkonda, Ph.D. (Georgia Tech) collaborated on this research using nanomedicine to trap the migrating cells in brain tumors.
    • Peds Winter 2010 issue features the article "Brain Exvaders," which discusses the novel bioengineering solution aimed at pediatric brain tumors.
    • Reporter Newspapers interview Children's neurosurgeon, Dr. Brahma, about the exciting new research to remove brain tumors involving teams from Children's, Georgia Tech and Emory University School of Medicine.

    Stem Cells
    Tracy-Ann Read, Ph.D., Research Scientist, is studying medulloblastoma and cancer stem cells in the central nervous system, in conjunction with Emory Department of Neurosurgery.

    Brain Tumor Staining 
    Barun Brahma, M.D., Pediatric Neurosurgeon, and Ravi Bellamkonda, Ph.D. (Georgia Tech) are conducting a donor funded research study to use nano-technology to better assist surgeons in distinguishing brain tumors form healthy brain tissue. Learn more.

    Drug Therapy
    Tobey MacDonald, M.D., Director, Neuro-Oncology Program, is leading a study to develop a drug therapy to stop the spread of medulloblastoma as an alternative to radiation therapy.

    Traumatic Brain Injury

    Emory University/Georgia Institute of Technology Grant - An investigation of coagulopathy after sever traumatic brain injury in children with emphasis on the role of platelet dysfunction. Investigators: Andrew Reisner, M.D., Jeanne Hendrickson, Joshua J. Chern, M.D., Ph.D., Silvia Bunting, M.D. et al.

Neuropsychology

Cognitive Remediation
We are currently examining the effectiveness of our cognitive remediation program by utilzing pre- and post-testing control patients who have not been through our cognitive remediation program and comparing them with those patients who have received cognitive remediation.

Neurodevelopmental Issues associated with Congenital Heart Disease
The team is analyzing one and two-year neurodevelopmental follow-up in children with congenital heart disease to look at inflammatory markers related to brain injury pre- and post-open heart surgery.

We are also looking at the cognitive effects of congenital cardiac disease in an fMRI and DTI study.

Concussion
Comparing concussed atheletes with normal controls to assess advanced neuroimaging techniques as it pertains to return to play decisions.

Spine
  • Spinal Cord Injury
    Research is currently underway with the Georgia Institute of Technology to decrease secondary injury due to spinal cord injury.

    Inside-outside occipital bolt in place of halos for children who require occipitocervical fusion
    Halos are an important part of the immobilization process, but they are difficult for pediatric patients. David Wrubel, M.D., and Dr. Brahma performed the first study to focus on the use of inside-outside occipital screws in children (including patients under 4) to avoid the use of halo orthosis. Our neurosurgeons found the screws to be a useful part of occipitocervical instrumentation in patients 2 to 15 years. This instrumentation has a higher pullout strength with a greater degree of immobilization, which limits the need for halo orthosis.

Resources