Brain Tumor Research

Through discovery, innovation and collaboration, researchers at the Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta are investigating new avenues regarding the metastasis of medulloblastoma as well as safer, more effective methods of treatment for children with brain tumors.

Clinical and Translational Research

  • Targeted Therapeutics
    • Targeted therapeutics involves the discovery of new drugs (targets) aimed at modifying the inappropriate behavior of cancer cells. Our physicians are currently conducting clinical trials to test identified targeted therapeutics for children with brain tumors.
  • Genomic Biomarkers
    • Insights into the biology of pediatric brain tumors have led to clinical trials to test identified targeted therapeutics for children.
  • Nanotechnology
    • Children’s is home to the first Center for Pediatric Nanomedicine in the nation. In conjunction with Emory, Georgia Tech and Morehouse, physicians and engineers will develop targeted, molecular-sized nanoparticles as part of a unique approach to treating pediatric diseases, such as pediatric brain tumors. Nanomedicine has the potential to profoundly improve, if not completely revolutionize, the treatment, care and ultimate cure of childhood diseases and conditions.
  • Find a clinical trial

Clinical and Translational Researchers

Brain Tumor Research (4 Related Videos)

Brain Tumor ResearchView Pediatric ResearchView Clinical Research View EUREKA Grant View
Dr. Tobey MacDonald discusses research efforts for the Brain Tumor Program at the Aflac Cancer and Blood Disorders Center.

    A novel bioengineering solution aimed at pediatric brain tumors could someday help eradicate almost any kind of tumor. This solution was recognized by the NIH with one of only seven EUREKA grants awarded by the National Cancer Institute. Learn more.


Basic Research

  • Regulation of Medulloblastoma Metastasis (therapeutic target)
    • Dr. Tobey MacDonald is working to develop a drug therapy that stops the spread of medulloblastoma as an alternative to the often-damaging whole brain radiation therapy that now follows surgery to remove a brain tumor. Currently, the research is focused specifically on medulloblastoma, however, if the approach is successful, it could potentially be applied to any kind of tumor anywhere in the body. Learn more
  • Oncogenic Signaling in Medulloblastoma
    • Dr. Robert Castellino is conducting research in hopes of finding a gentler cure for medulloblastoma by focusing on the gene called wild-type p53-induced phosphatase—abbreviated as WIP1. Learn more

Basic Researchers

Research Collaborations

The Aflac Cancer Center Neuro-Oncology Program conducts leading-edge research in conjunction with the following local, regional and national organizations: