We are one of only 16 pediatric centers around the country participating in ChiLDREN

The Childhood Liver Disease Research and Education Network (ChiLDREN) is a group of research institutions organized to study rare childhood liver diseases. It is sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a division of the National Institutes of Health (NIH). 

ChiLDREN’s combines:

  • Biliary Atresia Research Consortium (BARC)
  • Cholestatic Liver Disease Consortium (CLiC)
  • New studies on cystic fibrosis liver disease (CFLD)

The goals of ChiLDREN include:

  • Facilitate the discovery of causes of childhood liver disease
  • Develop new diagnostics tests or disease markers
  • Develop treatment options for children with liver disease and those who undergo liver transplant
  • Train the next generation of investigators in rare pediatric liver diseases

Diseases studied by the network include:

  • Alagille syndrome
  • Alpha 1 antitrypsin deficiency (A-1AT)
  • Bile acid synthesis and metabolic defects
  • Biliary atresia
  • Cystic fibrosis liver disease
  • Idiopathic neonatal hepatitis
  • Mitochondrial hepatopathies
  • Progressive familial intrahepatic cholestasis

The name of the protocols that are a part of ChiLDREN is in bold:

  • PROBE  : Prospective Database of Infants with Cholestasis
    A study of infants up to age 6 months with jaundice from liver disease
  • START  : Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants with Biliary Atresia
    A study to evaluate the usefulness of prednisone after surgery for biliary atresia
  • BASIC  : Biliary Atresia Study in Infants and Children
    A study to gather information on children with biliary atresia to understand what happens after the Kasai surgery
  • LOGIC  : Longitudinal Studies in Children with Cholestasis
    This study involves children with alpha-1 antitrypsin deficiency, Alagille syndrome, Progressive familial intrahepatic cholestasis and bile acid defects
  • MITOHEP  : Longitudinal Studies of Mitochondrial Hepatopathies
    A study to gather information about liver problems in mitochondrial diseases and in fatty oxidation defects