BMT Research

Through discovery, innovation and collaboration, researchers at the Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta are focusing their efforts on improving the clinical outcomes in children undergoing BMT.

Clinical and Translational Research

  • BMT for inherited diseases
  • Alternate donor BMT (unrelated, mismatched, haploidentical, cord blood)
  • Mechanisms of stem cell engraftment and creation of tolerance
  • Pathophysiology of sickle cell disease
  • The role and regulation of endothelial chemokines in pathologic conditions
  • Immunotherapy and innovative therapies
  • Find a clinical trial

Over the past few years, the Aflac Cancer Center BMT Program has experienced rapid growth in the number of Aflac Cancer Center-initiated clinical trials, with close ties to translational research.

Clinical and Translational Researchers

Basic Research

  • Identifying the major barriers to the acquisition of transplant tolerance in a highly immunologically active model of a non-malignant hematologic disease, such as sickle cell
  • Identifying how natural killer cells impact the acquisition of transplantation tolerance
  • Identifying the major barriers to the acquisition of transplantation tolerance in the non-human primate model
  • Identifying the barriers to tolerance that result in GvHD during BMT in a rhesus macaque model
  • Cell and biological therapy for cancer and immune ailments
  • Exploring the utility of stem cells for regenerative medicine, immune modulation and for delivery of therapeutic proteins for treatment of acquired and hereditary diseases

The Aflac Cancer Center BMT Program is a national leader in primate transplantation research—we are home to the only primate GvHD model in the country.

Basic Researcher

Research Collaborations

The Aflac Cancer Center BMT Program conducts leading-edge research in conjunction with the following local, regional and national organizations: