Transfusion Medicine

Clinical Research

  • Transfusion transmitted CMV
  • Potential adverse effects of stored red blood cells
  • Alloimmunization in sickle cell patients
  • Development of a pediatric transfusion medicine training curriculum
  • Transfusion medicine and hemostasis network trials

Clinical Researcher

Basic Research

  • Red blood cell alloimmunization
  • BMT rejection primed by red blood cell or platelet transfusions
  • Red blood cell autoimmunity
  • Red blood cell antigen loss

Basic Researcher

  • James Zimring, M.D., Ph.D.

Recent Publications

  • Blajchman MA, Glynn SA, Josephson CD, Kleinman SH. Clinical Trial Opportunities in Transfusion Medicine:  Proceedings of an NHLBI State-Of-The-Science Symposium.  Transfus Med Rev 2010;4:259-285.  
  • Gilson CR, Cadwell CM, Smith NH, Hendrickson JE, Zimring JC. MHC II on transfused murine blood is not required for alloimmunization against MHC I.  Vox Sang. 2010;99:369-74.
  • Hendrickson, JE, Hod, EA, Spitalnik SL, Hillyer CD, Zimring, JC.  Storage of murine RBCs enhances alloantibody responses to an erythroid specific model antigen.  Transfusion 2010, 50(3): 642-648.
  • Hod EA, Arinsburg SA, Francis RO, Hendrickson JE, Zimring JC, Spitalnik SL. Use of mouse models to study the mechanisms and consequences of RBC clearance. Vox Sang. 2010;99:99-111.
  • Hod, EA, Zhang, N, Sokol, SA, Wojczyk BS, Francis, RO, Ansaldi D, Francis, KP, Della-Latta, P, Whittier, S, Sheth, S, Hendrickson, JE, Zimring, JC, Brittenham, GM, Spitalnik, SL.  Transfusion of RBCs after prolonged storage produces harmful effects that are mediated by iron and inflammation.  Blood, 2010;115:4284-92.
  • Hudson KE, Lin E, Hendrickson JE, Lukacher AE, Zimring JC: Regulation of primary alloantibody response through antecedent exposure to a microbial T cell epitope.  Blood;115:3989-96.
  • Josephson CD, Castillejo MI, Grima K, Hillyer CD.  ABO-mismatched platelet transfusions:  Strategies to mitigate patient exposure to naturally occurring hemolytic antibodies.  Transfusion and Apheresis Science 2010;42:83-88.
  • Josephson CD, Wesolowski A, Sola-Visner MC, Dudell G, Easley KA, Castillejo MI, Bao G, Shaz BH, Hillyer CD, Maheshwari A. Do Red Cell Transfusions Increase the Risk of Necrotizing Enterocolitis in Premature Infants?  J Pediatr  2010;157:972-978.
  • Sanchez R, Sloan SR, Josephson CD, Ambruso DR, Hillyer CD, O’Sullivan P.  Consensus Recommendations of Pediatric Transfusion Medicine Objectives for Clinical Pathology Residency Training Programs.  Transfusion 2010;50:1071-78.
  • Schmotzer CL, Brown A, Roth S, Castillejo MI, Johnson J, Hillyer CD, Josephson CD.   Evaluation of an Optimal Preparation to Transfusion Volume Ratio in Pediatric Surgical Patients. Transfusion 2010;50:861-67.
  • Slichter SJ, Kaufman R, Assmann SF, McCullough J, Triuluzi D, Strauss RG, Gernsheimer TB, Ness PM, Brecher ME, Josephson CD, Konkle B, Woodson RD, Ortel T, Hillyer CD, Skerrett DL, McCrae K, Sloan SR, Uhl L, George JN, Buchannan G, Manno C, McFarland JG, Hess JR, Leissinger C, Granger S.  Effects of Platelet Dose on Transfusion Outcomes (The PLADO TRIAL, A Transfusion Medicine/Hemostasis Clinical Trials Network Study).  N Engl J Med   2010;362:600-13.
  • Winkler A, Culler EE, Emory MR, Duncan A, Castillejo MI, Jessup PL, Myers RL, Hillyer CD, Josephson CD.  Small Volume Storage of Apheresis Platelets for Pediatric Use:  A Study of Platelet Metabolism and Function.  Transfusion 2010;50:2193-98.
  • Zimring JC: Recent developments and future directions of alloimmunization to transfused blood products.  Clin Lab Med 2010;30:467-73.

Research Collaborations