ATLANTA (Sept. 13, 2018) – The National Institutes of Health (NIH) has awarded a four-year, $3 million grant to a research team working in the labs of Wilbur Lam, MD, PhD, a Pediatric Hematologist/Oncologist at the Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, and Melissa Kemp, PhD, who are both associate professors in the Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University School of Medicine, and in the University of Minnesota lab of David Wood, PhD.
The research team at Emory University Georgia Tech will use new technologies to improve the effectiveness of blood transfusions in patients with sickle cell disease. The NIH-funded project is titled “Redefining clinical viscosity in sickle cell disease by leveraging microfluidic technologies.”
Sickle cell disease is a life-threatening genetic blood disorder in which red blood cells become physically altered and misshapen. Viscosity, or resistance to flow, is a complex biophysical property of blood that changes in various parts of the circulation in the body and is rendered even more complex by sickle cell disease.
"While blood viscosity in sickle cell disease is poorly understood,” explained Dr. Lam, “it remains important clinically, because physicians are instructed to use blood transfusions judiciously to avoid ‘hyperviscosity,’ but are also hampered by clinical transfusion guidelines that are not scientifically sound or evidence-based.”
The researchers propose to use new microfluidic and computational modeling techniques to model the different blood vessels and to more precisely define what viscosity means in different parts of the circulation within a patient with sickle cell disease. They also will study how viscosity changes in the context of blood transfusions, which will lead to more patient-specific transfusion guidelines.
"We are grateful for this funding, and confident that the grant will allow us to make a significant contribution to redefining and improving guidelines for blood transfusions in sickle cell disease,” Dr. Kemp said. “This could make a significant difference in the quality of life and long-term health of these patients.”